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rabbit α α2 b  (Alomone Labs)


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    Alomone Labs rabbit α α2 b
    Rabbit α α2 B, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 92/100, based on 12 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/rabbit α α2 b/product/Alomone Labs
    Average 92 stars, based on 12 article reviews
    rabbit α α2 b - by Bioz Stars, 2026-02
    92/100 stars

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    The effect of ARC 239, a specific antagonist of the α2B isoform, on the guanabenz-induced suppression of I CaL . ( a , b ) Representative time-courses of peak I CaL density values of guanabenz (guan)-induced suppression of I CaL in the absence and presence of the antagonist ARC 239. Horizontal bars denote the protocol of the drug applications. ( c ) ARC 239 induced a minor rightward shift of dose-dependent inhibition of I CaL at the lower concentrations of guanabenz.

    Journal: International Journal of Molecular Sciences

    Article Title: Role of α2-Adrenoceptor Subtypes in Suppression of L-Type Ca 2+ Current in Mouse Cardiac Myocytes

    doi: 10.3390/ijms22084135

    Figure Lengend Snippet: The effect of ARC 239, a specific antagonist of the α2B isoform, on the guanabenz-induced suppression of I CaL . ( a , b ) Representative time-courses of peak I CaL density values of guanabenz (guan)-induced suppression of I CaL in the absence and presence of the antagonist ARC 239. Horizontal bars denote the protocol of the drug applications. ( c ) ARC 239 induced a minor rightward shift of dose-dependent inhibition of I CaL at the lower concentrations of guanabenz.

    Article Snippet: Proteins were separated in 10% SDS-PAGE, transferred to nitrocellulose membranes (sc-3724, 0.45 µm, Santa Cruz Biotechnology) and probed with antibodies against α2A (AAR-020, Alomone labs, lot AAR020AN0202), α2B (AAR-021, Alomone labs, lot AAR021AN0202) and α2C (ab46536, Abcam) diluted to 1:100.

    Techniques: Inhibition

    The mRNA and protein expression levels of the α2-AR isoforms in the mouse left ventricle. ( a ) mRNA expression of the α2 adrenoceptor genes obtained using the RT-qPCR assay. In contrast to adra2B and adrs2C genes the expression of adra2A was not detected (ND). ( b ) Western blots confirmed the expression of α2B and α2C but not α2A receptor proteins in the mouse left ventricular tissue.

    Journal: International Journal of Molecular Sciences

    Article Title: Role of α2-Adrenoceptor Subtypes in Suppression of L-Type Ca 2+ Current in Mouse Cardiac Myocytes

    doi: 10.3390/ijms22084135

    Figure Lengend Snippet: The mRNA and protein expression levels of the α2-AR isoforms in the mouse left ventricle. ( a ) mRNA expression of the α2 adrenoceptor genes obtained using the RT-qPCR assay. In contrast to adra2B and adrs2C genes the expression of adra2A was not detected (ND). ( b ) Western blots confirmed the expression of α2B and α2C but not α2A receptor proteins in the mouse left ventricular tissue.

    Article Snippet: Proteins were separated in 10% SDS-PAGE, transferred to nitrocellulose membranes (sc-3724, 0.45 µm, Santa Cruz Biotechnology) and probed with antibodies against α2A (AAR-020, Alomone labs, lot AAR020AN0202), α2B (AAR-021, Alomone labs, lot AAR021AN0202) and α2C (ab46536, Abcam) diluted to 1:100.

    Techniques: Expressing, Quantitative RT-PCR, Western Blot